Reference managing software simplifies research publication. You don't need to keep track of who you cited, in what order, or whether your reference list includes only who you cited in the paper. Software such as Endnote and Mendeley partially automate these time-consuming tasks and make your research life easier.Unfortunately, reference managing software is not interchangeable. A MS Word document that is formatted using Mendeley, cannot be then formatted with Endnote. Reference lists though, can be interchanged between software. Therefore you can use Mendeley with one research article and Endnote for another.For each research article, it is best to have all authors use the same piece of software. However how do you choose? Which is better? "Better" is often subjective. Each piece of software has their own strengths and weaknesses. In this guide, we will compare Endnote vs Mendeley to help with your decision making.